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Treatment of hepatitis B virus-associated glomerulonephritis: a meta-analysis Zhang Y; Zhou JH; Yin XL; Wang FYWorld J Gastroenterol 2010[Feb]; 16 (6): 770-7AIM: To evaluate the efficacy of antiviral or corticosteroid treatment on hepatitis B virus-associated glomerulonephritis (HBV-GN). METHODS: Six and five trials were used respectively to evaluate the efficacy of either antiviral or corticosteroid treatment on HBV-GN. Pediatric patients were pooled separately to assess their response to the above treatment modalities. The primary and secondary outcomes were remission of proteinuria and clearance of Hepatitis B e-antigen (HBeAg), respectively. A fixed or random effect model was established to collect the data. RESULTS: The remission rate of proteinuria (RR = 1.69, 95% CI: 1.08-2.65) and the clearance rate of HBeAg (RR = 6.44, 95% CI: 3.11-13.35) were significantly higher in antiviral treatment group than in control group. The proteinuria remission was significantly associated with HBeAg clearance (P = 0.002). However, the difference in proteinuria remission rate was not statistically significant between corticosteroid treatment group and control group (RR = 1.45, 95% CI: 0.68-3.11). Antiviral therapy could significantly promote the HBeAg clearance in pediatric patients, but neither antiviral nor corticosteroid therapy could significantly decrease proteinuria in pediatric patients compared to controls. CONCLUSION: Antiviral but not corticosteroid treatment can decrease proteinuria and promote HBeAg clearance in HBV-GN patients.|*Hepatitis B virus[MESH]|Adrenal Cortex Hormones/*therapeutic use[MESH]|Antiviral Agents/*therapeutic use[MESH]|Glomerulonephritis/*drug therapy/*virology[MESH]|Hepatitis B e Antigens/blood[MESH]|Hepatitis B/*drug therapy[MESH]|Humans[MESH]|Interferons/therapeutic use[MESH]|Lamivudine/therapeutic use[MESH]|Proteinuria/drug therapy[MESH]|Treatment Outcome[MESH] |
