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Mechanisms involved in antibody- and complement-mediated allograft rejection Wasowska BAImmunol Res 2010[Jul]; 47 (1-3): 25-44Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcgamma receptors and complement receptors.|Animals[MESH]|Complement Activation/*immunology[MESH]|Disease Models, Animal[MESH]|Endothelial Cells/pathology[MESH]|Graft Rejection/immunology/*pathology[MESH]|Heart Transplantation/immunology[MESH]|Humans[MESH]|Isoantibodies/*immunology[MESH]|Macrophages/immunology[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Monocytes/immunology[MESH] |
