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lüll Protein S-nitrosylation and cardioprotection Sun J; Murphy ECirc Res 2010[Feb]; 106 (2): 285-96Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group. There are emerging data suggesting that S-nitrosylation of proteins plays an important role in cardioprotection. Protein S-nitrosylation not only leads to changes in protein structure and function but also prevents these thiol(s) from further irreversible oxidative/nitrosative modification. A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases.|*Protein Processing, Post-Translational[MESH]|Animals[MESH]|Calcium/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Myocardium/*metabolism[MESH]|Nitric Oxide/*metabolism[MESH]|Oxidation-Reduction[MESH]|S-Nitrosothiols/metabolism[MESH]|Sulfhydryl Compounds/*metabolism[MESH] |