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lüll Update in vitamin D Adams JS; Hewison MJ Clin Endocrinol Metab 2010[Feb]; 95 (2): 471-8The past decade, particularly the last 18 months, witnessed a vigorous increase in interest in vitamin D from both the lay and biomedical worlds. Much of the growing interest in vitamin D is powered by new data being extracted from the National Health and Nutrition Examination Survey (NHANES). The newest statistics demonstrate that more than 90% of the pigmented populace of the United States (Blacks, Hispanics, and Asians) now suffer from vitamin D insufficiency (25-hydroxyvitamin D <30 ng/ml), with nearly three fourths of the white population in this country also being vitamin D insufficient. This represents a near doubling of the prevalence of vitamin D insufficiency seen just 10 yr ago in the same population. This review attempts to provide some explanation for: 1) the rapid decline in vitamin D status in the United States; 2) the adverse impact of vitamin D insufficiency on skeletal, infectious/inflammatory, and metabolic health in humans; and 3) the therapeutic rationale and reliable means for vigorous supplementation of our diets with vitamin D.|*Vitamin D Deficiency/complications/epidemiology/therapy[MESH]|Animals[MESH]|Bacterial Infections/immunology[MESH]|Bone Density[MESH]|Calcitriol/biosynthesis[MESH]|Cardiovascular Diseases/mortality[MESH]|Humans[MESH]|Metabolic Syndrome/etiology[MESH]|Vitamin D/analogs & derivatives/blood/physiology[MESH] |