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lüll Protein-phospholipid interactions in blood clotting Morrissey JH; Davis-Harrison RL; Tavoosi N; Ke K; Pureza V; Boettcher JM; Clay MC; Rienstra CM; Ohkubo YZ; Pogorelov TV; Tajkhorshid EThromb Res 2010[Apr]; 125 Suppl 1 (ä): S23-5Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions.|*Blood Coagulation[MESH]|Algorithms[MESH]|Cell Membrane/metabolism[MESH]|Computer Simulation[MESH]|Factor VIIa/chemistry[MESH]|Humans[MESH]|Magnetic Resonance Spectroscopy/methods[MESH]|Models, Biological[MESH]|Nanotechnology/methods[MESH]|Phospholipids/*chemistry[MESH]|Protein Structure, Tertiary[MESH]|Proteins/*chemistry[MESH]|Serine Proteases/chemistry[MESH]|Thromboplastin/metabolism[MESH] |