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  • Identity of mysterious CD4+CD25-Foxp3+ cells in SLE
  • Horwitz DA
  • Arthritis Res Ther 2010[]; 12 (1): 101
  • Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity.
  • |Forkhead Transcription Factors/immunology[MESH]
  • |Humans[MESH]
  • |Interleukin-2 Receptor alpha Subunit/immunology[MESH]
  • |Lupus Erythematosus, Systemic/*immunology[MESH]
  • |T-Lymphocyte Subsets/cytology/*immunology[MESH]
  • |T-Lymphocytes, Regulatory/cytology/*immunology[MESH]

  • *{{pmid20122288}}
    *<b>[ Identity of mysterious CD4+CD25-Foxp3+ cells in SLE ]</b> Arthritis Res Ther 2010; 12(1) ; 101 Horwitz DA


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    Arthritis Res Ther

    101 1.12 2010