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lüll Identity of mysterious CD4+CD25-Foxp3+ cells in SLE Horwitz DA Arthritis Res Ther 2010[]; 12 (1): 101 Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity. |Forkhead Transcription Factors/immunology[MESH] |Humans[MESH] |Interleukin-2 Receptor alpha Subunit/immunology[MESH] |Lupus Erythematosus, Systemic/*immunology[MESH] |T-Lymphocyte Subsets/cytology/*immunology[MESH] |T-Lymphocytes, Regulatory/cytology/*immunology[MESH]

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*<b>[http://www.kidney.de/mlpefetch.php?search=20122288 Identity of mysterious CD4+CD25-Foxp3+ cells in SLE ]</b> Arthritis Res Ther 2010; 12(1) ; 101 Horwitz DA

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{{recpmid|pmid=20122288|ti=Identity of mysterious CD4+CD25-Foxp3+ cells in SLE |au=Horwitz DA|so=Arthritis Res Ther 2010; 12 (1): 101|ab=Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity.}}
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{{BibRecord | Autor = Horwitz DA | Titel = Identity of mysterious CD4+CD25-Foxp3+ cells in SLE | Band = 12 | Nummer = 1 | Jahr = 2010 | Monat = | Sprache = eng | DOI = | Seite = 101 | PMID = 20122288 | Typ= {{{Typ|}}} | Kommentar = {{{Kommentar|}}} | format = {{{format|}}} | record = {{{record|}}} }}

Arthritis Res Ther