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The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study From AM; Scott CG; Chen HHJ Am Coll Cardiol 2010[Jan]; 55 (4): 300-5OBJECTIVES: The purpose of this study was to evaluate the outcomes of pre-clinical diastolic dysfunction in diabetic patients. BACKGROUND: Studies have reported a high prevalence of pre-clinical diastolic dysfunction among patients with diabetes mellitus. METHODS: We identified all diabetic patients with a tissue Doppler imaging assessment of diastolic function in Olmsted County, Minnesota, from 2001 to 2007. Diastolic dysfunction was defined as a passive transmitral left ventricular (LV) inflow velocity to tissue Doppler imaging velocity of the medial mitral annulus during passive filling (E/e') ratio >15. The main outcome was the development of heart failure (HF). Secondary outcomes were the development of atrial fibrillation and death. RESULTS: Overall, 1,760 diabetic patients with a tissue Doppler echocardiographic assessment of diastolic function were identified; 411 (23%) patients had diastolic dysfunction. Using multivariable Cox's proportional hazard modeling, we determined that for every 1-U increase in the passive transmitral LV inflow velocity to tissue Doppler imaging velocity of the medial mitral annulus during passive filling (E/e') ratio, the hazard ratio (HR) of HF increased by 3% (HR: 1.03; 95% confidence interval [CI]: 1.01 to 1.06; p = 0.006) and that diastolic dysfunction was associated with the subsequent development of HF after adjustment for age, sex, body mass index, hypertension, coronary disease, and echocardiographic parameters (HR: 1.61; 95% CI: 1.17 to 2.20; p = 0.003). The cumulative probability of the development of HF at 5 years for diabetic patients with diastolic dysfunction was 36.9% compared with 16.8% for patients without diastolic dysfunction (p < 0.001). Furthermore, diabetic patients with diastolic dysfunction had a significantly higher mortality rate compared with those without diastolic dysfunction. CONCLUSIONS: We demonstrated that an increase in the passive transmitral LV inflow velocity to tissue Doppler imaging velocity of the medial mitral annulus during passive filling (E/e') ratio in diabetic patients is associated with the subsequent development of HF and increased mortality independent of hypertension, coronary disease, or other echocardiographic parameters.|*Diabetes Complications/mortality/physiopathology[MESH]|Aged[MESH]|Atrial Fibrillation/etiology[MESH]|Echocardiography, Doppler[MESH]|Female[MESH]|Heart Failure, Diastolic/*etiology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Ventricular Dysfunction, Left[MESH] |
