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Towards building a chromosome segregation machine Bloom K; Joglekar ANature 2010[Jan]; 463 (7280): 446-56All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.|Animals[MESH]|Biomechanical Phenomena[MESH]|Cell Division/genetics[MESH]|Centromere/genetics[MESH]|Chromatin/metabolism[MESH]|Chromosome Segregation/*genetics[MESH]|DNA/chemistry[MESH]|Eukaryotic Cells/*cytology/physiology[MESH]|Humans[MESH]|Prokaryotic Cells/*cytology/physiology[MESH]|Protein Transport[MESH]|Spindle Apparatus/metabolism[MESH]|Thermodynamics[MESH] |
