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lüll Gene expression in the third dimension: the ECM-nucleus connection Spencer VA; Xu R; Bissell MJJ Mammary Gland Biol Neoplasia 2010[Mar]; 15 (1): 65-71Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Cell Nucleus/*metabolism[MESH]|Cytoskeleton/metabolism[MESH]|Extracellular Matrix/*physiology[MESH]|Female[MESH]|Humans[MESH]|Mammary Glands, Animal/physiology[MESH]|Mammary Glands, Human/physiology[MESH]|Organ Specificity/physiology[MESH]|STAT5 Transcription Factor/physiology[MESH]|Signal Transduction[MESH] |