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lüll Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition Deslandes S; Chassaing S; Delfourne EMar Drugs 2009[Dec]; 7 (4): 754-86Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.|Alkaloids/*chemical synthesis/chemistry/pharmacology[MESH]|Carbazoles/*chemical synthesis/chemistry/pharmacology[MESH]|Checkpoint Kinase 1[MESH]|Humans[MESH]|Imidazoles/chemical synthesis/chemistry/pharmacology[MESH]|Indoles/chemical synthesis/chemistry/pharmacology[MESH]|Marine Biology[MESH]|Protein Kinase Inhibitors/*chemical synthesis/chemistry/pharmacology[MESH]|Protein Kinases/chemistry/metabolism[MESH]|Pyrroles/*chemical synthesis/chemistry/pharmacology[MESH] |