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lüll Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels Ryu SY; Beutner G; Dirksen RT; Kinnally KW; Sheu SSFEBS Lett 2010[May]; 584 (10): 1948-55Ca(2+) channels that underlie mitochondrial Ca(2+) transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca(2+) uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca(2+) transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca(2+) overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca(2+) channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca(2+) channels.|Animals[MESH]|Calcium Channels/*metabolism[MESH]|Calcium/*metabolism[MESH]|Humans[MESH]|Mitochondria/*metabolism[MESH]|Permeability[MESH]|Ryanodine Receptor Calcium Release Channel/*metabolism[MESH]|Signal Transduction[MESH] |