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lüll Electrophysiological remodeling in heart failure Wang Y; Hill JAJ Mol Cell Cardiol 2010[Apr]; 48 (4): 619-32Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.|Animals[MESH]|Anisotropy[MESH]|Arrhythmias, Cardiac/physiopathology[MESH]|Atrioventricular Node/physiopathology[MESH]|Electrophysiology/*methods[MESH]|Gap Junctions[MESH]|Heart Failure/*physiopathology[MESH]|Heart/physiopathology[MESH]|Humans[MESH]|Myocardial Contraction[MESH]|Myocardium/pathology[MESH]|Potassium/chemistry[MESH]|Purkinje Cells/metabolism[MESH]|Rats[MESH] |