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Cell type-specific regulation of IL-10 expression in inflammation and disease Hedrich CM; Bream JHImmunol Res 2010[Jul]; 47 (1-3): 185-206IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate temporal/spatial expression of IL-10 may be the key to how IL-10 contributes to the delicate balance between inflammation and immunoregulation. The mechanisms that govern the cell type- and receptor-specific induction of IL-10, however, remain unclear. This is due largely to the wide distribution of cellular sources that express IL-10 under diverse stimulation conditions and in a variety of tissue compartments. Further complicating the issue is the fact that human IL-10 expression patterns appear to be under genetic influence resulting in differential expression and disease susceptibility. In this review, we discuss the cellular sources of IL-10, their link to disease phenotypes and the molecular mechanisms implicated in IL-10 regulation.|*Immunity, Cellular[MESH]|Animals[MESH]|Autoimmune Diseases/*immunology[MESH]|Dendritic Cells/immunology/metabolism[MESH]|Gene Expression Regulation/*immunology[MESH]|Humans[MESH]|Infections/*immunology[MESH]|Inflammation/*immunology[MESH]|Interleukin-10/genetics/*metabolism[MESH]|Macrophages/immunology/metabolism[MESH]|Mice[MESH]|T-Lymphocytes/immunology/metabolism[MESH] |
