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lüll A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics Van Damme E; Laukens K; Dang TH; Van Ostade XInt J Biol Sci 2010[Jan]; 6 (1): 51-67Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling 'the PML-ome', we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot.|Algorithms[MESH]|Animals[MESH]|Cell Nucleus/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Nuclear Proteins/*metabolism[MESH]|Promyelocytic Leukemia Protein[MESH]|Protein Multimerization[MESH]|Signal Transduction[MESH]|Small Ubiquitin-Related Modifier Proteins/*metabolism[MESH]|Transcription Factors/*metabolism[MESH]|Tumor Suppressor Proteins/*metabolism[MESH]|Ubiquitination[MESH] |