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lüll TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion Wu Y; Zhou BPBr J Cancer 2010[Feb]; 102 (4): 639-44Tumour necrosis factor-alpha (TNF-alpha) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-alpha in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-alpha as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-alpha and the nuclear factor-kappaB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.|Animals[MESH]|Cell Movement/*genetics[MESH]|Cell Transformation, Neoplastic/genetics/pathology[MESH]|Humans[MESH]|Models, Biological[MESH]|NF-kappa B/genetics/*physiology[MESH]|Neoplasm Invasiveness[MESH]|Neoplasms/genetics/*pathology[MESH]|Snail Family Transcription Factors[MESH]|Transcription Factors/genetics/*physiology[MESH]|Tumor Necrosis Factor-alpha/genetics/*physiology[MESH] |