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TCF1 and beta-catenin regulate T cell development and function Yu Q; Sharma A; Sen JMImmunol Res 2010[Jul]; 47 (1-3): 45-55T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with beta-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the beta-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the beta-catenin gene and generated mutant mice that have shown an essential role for beta-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and beta-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.|*Cell Differentiation[MESH]|*Gene Expression Regulation[MESH]|Animals[MESH]|CD4-Positive T-Lymphocytes/immunology[MESH]|CD8-Positive T-Lymphocytes/immunology[MESH]|Humans[MESH]|Mice[MESH]|Receptors, Antigen, T-Cell/genetics/metabolism[MESH]|Signal Transduction[MESH]|T Cell Transcription Factor 1/genetics/*metabolism[MESH]|T-Lymphocytes/*cytology/*immunology/metabolism[MESH]|beta Catenin/genetics/*metabolism[MESH] |
