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lüll Antibody drug-conjugates targeting the tumor vasculature: Current and future developments Gerber HP; Senter PD; Grewal ISMAbs 2009[May]; 1 (3): 247-53Reducing the blood supply of tumors is one modality to combat cancer. Monoclonal antibodies are now established as a key therapeutic approach for a range of diseases. Owing to the ability of antibodies to selectively target endothelial cells within the tumor vasculature, vascular targeting programs have become a mainstay in oncology drug development. However, the antitumor activity of single agent administration of conventional anti-angiogenic compounds is limited and the improvements in patient survival are most prominent in combinations with chemotherapy. Furthermore, prolonged treatment with conventional anti-angiogenic drugs is associated with toxicity and drug resistance. These circumstances provide a strong rationale for novel approaches to enhance the efficacy of mAbs targeting tumor vasculature such as antibody-drug conjugates (ADCs).Here, we review trends in the development of ADCs targeting tumor vasculature with the aim of informing future research and development of this class of therapeutics.|Angiogenesis Inhibitors/adverse effects/therapeutic use[MESH]|Animals[MESH]|Antigens/immunology[MESH]|Blood Vessels/immunology[MESH]|Drug Design[MESH]|Drug Resistance[MESH]|Humans[MESH]|Immunotherapy/*trends[MESH]|Immunotoxins/*therapeutic use[MESH]|Neoplasms/blood supply/*drug therapy[MESH]|Neovascularization, Pathologic/*drug therapy[MESH] |