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Ofatumumab Zhang BMAbs 2009[Jul]; 1 (4): 326-31Ofatumumab is an anti-CD20 IgG1kappa human monoclonal antibody that is being considered by the US Food and Drug Administration and the European Medicines Agency for marketing approval as a treatment for chronic lymphocytic leukemia. The mAb is also being studied as a treatment for lymphoma, rheumatoid arthritis and multiple sclerosis. The candidate targets the same antigen as rituximab, but ofatumumab binds a novel, membrane-proximal epitope, and dissociates from its target at a slower rate compared to rituximab. Ofatumumab might be approved in the US by August 2009.|Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/immunology/*therapeutic use[MESH]|Arthritis, Rheumatoid/*drug therapy/immunology[MESH]|Humans[MESH]|Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy/immunology[MESH]|Multiple Sclerosis/*drug therapy/immunology[MESH] |
