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Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD Eisenstein BI; Oleson FB Jr; Baltz RHClin Infect Dis 2010[Jan]; 50 Suppl 1 (ä): S10-5Daptomycin has been approved and successfully launched for the treatment of complicated skin and skin-structure infections caused by gram-positive pathogens [1] and bacteremia and right-sided endocarditis due to Staphylococcus aureus, including strains that are resistant to methicillin or other antibiotics [2]. The development of the drug, however, was not straightforward; it involved a cast of characters, including scientists at Eli Lilly and at Cubist Pharmaceuticals. Of most importance, the development of daptomycin involved the tenacious leadership of Dr. Francis Tally. As a tribute to Dr. Tally, we attempt to reconstruct the path of daptomycin from the mountain to the clinic.|*Anti-Bacterial Agents/chemistry/pharmacology/therapeutic use[MESH]|*Daptomycin/chemistry/pharmacology/therapeutic use[MESH]|*Drug Resistance, Bacterial[MESH]|Bacteremia/drug therapy/microbiology[MESH]|Clinical Trials as Topic[MESH]|Drug Approval[MESH]|Drug Design[MESH]|Endocarditis, Bacterial/drug therapy/microbiology[MESH]|Gram-Positive Bacteria/*drug effects[MESH]|Gram-Positive Bacterial Infections/*drug therapy/microbiology[MESH]|Humans[MESH]|Microbial Sensitivity Tests[MESH]|Skin Diseases, Bacterial/drug therapy/microbiology[MESH]|Soft Tissue Infections/drug therapy/microbiology[MESH]|Staphylococcus aureus/drug effects[MESH] |
