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English Wikipedia
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Dental enamel: genes define biomechanics Rauth RJ; Potter KS; Ngan AY; Saad DM; Mehr R; Luong VQ; Schuetter VL; Miklus VG; Chang P; Paine ML; Lacruz RS; Snead ML; White SNJ Calif Dent Assoc 2009[Dec]; 37 (12): 863-8Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.|Amelogenin/genetics[MESH]|Animals[MESH]|Biomechanical Phenomena[MESH]|Dental Enamel Proteins/*genetics[MESH]|Dental Enamel/*physiology[MESH]|Extracellular Matrix Proteins/genetics[MESH]|Gene Expression Regulation/genetics[MESH]|Kallikreins/genetics[MESH]|Mice[MESH]|Models, Animal[MESH]|Phosphoproteins/genetics[MESH]|Sialoglycoproteins/genetics[MESH]|Sodium-Bicarbonate Symporters/genetics[MESH]|Tooth Calcification/genetics[MESH] |
