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lüll High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation Luznik L; Fuchs EJImmunol Res 2010[Jul]; 47 (1-3): 65-77Graft-versus-host disease, or GVHD, is a major complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) for the treatment of hematologic malignancies. Here, we describe a novel method for preventing GVHD after alloHSCT using high-dose, post-transplantation cyclophosphamide (Cy). Post-transplantation Cy promotes tolerance in alloreactive host and donor T cells, leading to suppression of both graft rejection and GVHD after alloHSCT. High-dose, post-transplantation Cy facilitates partially HLA-mismatched HSCT without severe GVHD and is effective as sole prophylaxis of GVHD after HLA-matched alloHSCT. By reducing the morbidity and mortality of alloHSCT, post-transplantation Cy may expand the applications of this therapy to the treatment of autoimmune diseases and non-malignant hematologic disorders such as sickle cell disease.|*Hematopoietic Stem Cell Transplantation/methods[MESH]|Animals[MESH]|Clinical Trials as Topic[MESH]|Cyclophosphamide/*administration & dosage/immunology[MESH]|Female[MESH]|Graft vs Host Disease/immunology/prevention & control[MESH]|Hematologic Neoplasms/therapy[MESH]|Humans[MESH]|Immunosuppressive Agents/*administration & dosage/immunology[MESH]|Male[MESH]|Mice[MESH]|Middle Aged[MESH]|Transplantation Tolerance/*drug effects/immunology[MESH]|Transplantation, Homologous/*immunology[MESH] |