Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Adhesive and signaling functions of cadherins and catenins in vertebrate development Stepniak E; Radice GL; Vasioukhin VCold Spring Harb Perspect Biol 2009[Nov]; 1 (5): a002949Properly regulated intercellular adhesion is critical for normal development of all metazoan organisms. Adherens junctions play an especially prominent role in development because they link the adhesive function of cadherin-catenin protein complexes to the dynamic forces of the actin cytoskeleton, which helps to orchestrate a spatially confined and very dynamic assembly of intercellular connections. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are linked to several major developmental signaling pathways crucial for normal morphogenesis. In this article we will highlight the key genetic studies that uncovered the role of cadherin-catenin proteins in vertebrate development and discuss the potential role of these proteins as molecular biosensors of external cellular microenvironment that may spatially confine signaling molecules and polarity cues to orchestrate cellular behavior throughout the complex process of normal morphogenesis.|*Gene Expression Regulation[MESH]|Actins/chemistry[MESH]|Adherens Junctions/metabolism[MESH]|Animals[MESH]|Brain/metabolism[MESH]|Cadherins/*metabolism[MESH]|Catenins/*metabolism[MESH]|Cell Adhesion[MESH]|Cell Proliferation[MESH]|Central Nervous System/metabolism[MESH]|Developmental Biology/methods[MESH]|Models, Biological[MESH]|Neural Crest/metabolism[MESH]|Signal Transduction[MESH] |