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Robust generation and decoding of morphogen gradients Barkai N; Shilo BZCold Spring Harb Perspect Biol 2009[Nov]; 1 (5): a001990Morphogen gradients play a key role in multiple differentiation processes. Both the formation of the gradient and its interpretation by the receiving cells need to occur at high precision to ensure reproducible patterning. This need for quantitative precision is challenged by fluctuations in the environmental conditions and by variations in the genetic makeup of the developing embryos. We discuss mechanisms that buffer morphogen profiles against variations in gene dosage. Self-enhanced morphogen degradation and pre-steady-state decoding provide general means for buffering the morphogen profile against fluctuations in morphogen production rate. A more specific "shuttling" mechanism, which establishes a sharp and robust activation profile of a widely expressed morphogen, and enables the adjustment of morphogen profile with embryo size, is also described. Finally, we consider the transformation of the smooth gradient profile into sharp borders of gene expression in the signal-receiving cells. The integration theory and experiments are increasingly used, providing key insights into the system-level functioning of the developmental system.|*Gene Expression Regulation[MESH]|Animals[MESH]|Body Patterning[MESH]|Bone Morphogenetic Proteins/metabolism[MESH]|Cell Differentiation[MESH]|Cell Lineage[MESH]|Gene Dosage[MESH]|Ligands[MESH]|Models, Biological[MESH]|Models, Theoretical[MESH]|Morphogenesis/*physiology[MESH]|Signal Transduction[MESH]|Xenopus[MESH] |
