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lüll A structural guide to proteins of the NF-kappaB signaling module Huxford T; Ghosh GCold Spring Harb Perspect Biol 2009[Sep]; 1 (3): a000075The prosurvival transcription factor NF-kappaB specifically binds promoter DNA to activate target gene expression. NF-kappaB is regulated through interactions with IkappaB inhibitor proteins. Active proteolysis of these IkappaB proteins is, in turn, under the control of the IkappaB kinase complex (IKK). Together, these three molecules form the NF-kappaB signaling module. Studies aimed at characterizing the molecular mechanisms of NF-kappaB, IkappaB, and IKK in terms of their three-dimensional structures have lead to a greater understanding of this vital transcription factor system.|*Signal Transduction[MESH]|Animals[MESH]|DNA/chemistry[MESH]|Dimerization[MESH]|Humans[MESH]|I-kappa B Proteins/*metabolism[MESH]|Models, Biological[MESH]|Molecular Conformation[MESH]|NF-kappa B/*metabolism[MESH]|Proteasome Endopeptidase Complex/chemistry[MESH]|Protein Binding[MESH]|Protein Conformation[MESH]|Protein Structure, Tertiary[MESH]|Transcription Factor RelA/chemistry[MESH] |