Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Specification of DNA binding activity of NF-kappaB proteins Wan F; Lenardo MJCold Spring Harb Perspect Biol 2009[Oct]; 1 (4): a000067Nuclear factor-kappaB (NF-kappaB) is a pleiotropic mediator of inducible and specific gene regulation involving diverse biological activities including immune response, inflammation, cell proliferation, and death. The fine-tuning of the NF-kappaB DNA binding activity is essential for its fundamental function as a transcription factor. An increasing body of literature illustrates that this process can be elegantly and specifically controlled at multiple levels by different protein subsets. In particular, the recent identification of a non-Rel subunit of NF-kappaB itself provides a new way to understand the selective high-affinity DNA binding specificity of NF-kappaB conferred by a synergistic interaction within the whole complex. Here, we review the mechanism of the specification of DNA binding activity of NF-kappaB complexes, one of the most important aspects of NF-kappaB transcriptional control.|Animals[MESH]|B-Lymphocytes/metabolism[MESH]|Chromatin/chemistry[MESH]|DNA/*chemistry[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Models, Biological[MESH]|NF-kappa B/*metabolism[MESH]|Nuclear Proteins/*metabolism[MESH]|Protein Binding[MESH]|Transcription Factor RelA/metabolism[MESH]|Transcription Factors/metabolism[MESH] |