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Large conformational changes in proteins: signaling and other functions Grant BJ; Gorfe AA; McCammon JACurr Opin Struct Biol 2010[Apr]; 20 (2): 142-7Guanine and adenine nucleotide triphosphatases, such as Ras proteins and protein kinases, undergo large conformational changes upon ligand binding in the course of their functions. New computer simulation methods have combined with experimental studies to deepen our understanding of these phenomena. In particular, a 'conformational selection' picture is emerging, where alterations in the relative populations of pre-existing conformations can best describe the conformational switching activity of these important proteins.|*Protein Conformation[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Humans[MESH]|Models, Molecular[MESH]|Protein Kinases/chemistry/metabolism[MESH]|Proteins/*chemistry/metabolism[MESH]|ras GTPase-Activating Proteins/chemistry/metabolism[MESH] |
