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Genome packaging in viruses Sun S; Rao VB; Rossmann MGCurr Opin Struct Biol 2010[Feb]; 20 (1): 114-20Genome packaging is a fundamental process in a viral life cycle. Many viruses assemble preformed capsids into which the genomic material is subsequently packaged. These viruses use a packaging motor protein that is driven by the hydrolysis of ATP to condense the nucleic acids into a confined space. How these motor proteins package viral genomes had been poorly understood until recently, when a few X-ray crystal structures and cryo-electron microscopy (cryo-EM) structures became available. Here we discuss various aspects of genome packaging and compare the mechanisms proposed for packaging motors on the basis of structural information.|*Virus Assembly[MESH]|Animals[MESH]|DNA Packaging[MESH]|DNA, Viral/chemistry/genetics/metabolism[MESH]|Genome, Viral/*genetics[MESH]|RNA, Viral/chemistry/genetics/metabolism[MESH]|Rotation[MESH]|Static Electricity[MESH]|Viruses/*genetics[MESH] |
