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lüll Macrophages: do they impact AIDS progression more than CD4 T cells?Kuroda MJJ Leukoc Biol 2010[Apr]; 87 (4): 569-73Destruction of CD4(+) T cells is considered to be the main cause of immunodeficiency manifested by opportunistic infections in HIV-1-infected humans, as well as in SIV-infected macaques. We propose that monocyte/macrophage lineage cells also play an important role in the pathogenesis of AIDS, based on our recent work with the SIV/rhesus macaque animal model. We propose that damage to CD4(+) T cells is important and readily apparent, but damage to monocyte/macrophage lineage cells, although less obvious, may provide the missing link to predict the onset of opportunistic infections and progression to AIDS.|Acquired Immunodeficiency Syndrome/*immunology/pathology[MESH]|Animals[MESH]|CD4-Positive T-Lymphocytes/*immunology/pathology/virology[MESH]|Disease Models, Animal[MESH]|HIV-1/*immunology/pathogenicity[MESH]|Humans[MESH]|Macaca mulatta[MESH]|Macrophages/*immunology/pathology/virology[MESH]|Simian Acquired Immunodeficiency Syndrome/immunology/pathology[MESH]|Simian Immunodeficiency Virus/immunology/pathogenicity[MESH] |