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  • Role of A-type lamins in signaling, transcription, and chromatin organization
  • Andres V; Gonzalez JM
  • J Cell Biol 2009[Dec]; 187 (7): 945-57
  • A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone, and neuronal tissues. In this review, we discuss recent research supporting the concept that lamin A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors, and chromatin-associated proteins.
  • |*Gene Expression Regulation[MESH]
  • |*Signal Transduction[MESH]
  • |Chromatin/*metabolism[MESH]
  • |Connectin[MESH]
  • |Lamin Type A/genetics/metabolism/*physiology[MESH]
  • |Membrane Proteins/genetics/metabolism/physiology[MESH]
  • |Models, Biological[MESH]
  • |Muscle Development[MESH]
  • |Muscle Proteins/metabolism[MESH]
  • |Nuclear Envelope/metabolism[MESH]
  • |Protein Kinases/metabolism[MESH]
  • |Receptors, Notch/metabolism/physiology[MESH]
  • |Transcription Factors/genetics/metabolism[MESH]
  • |Transcription, Genetic[MESH]
  • |Transforming Growth Factor beta/metabolism/physiology[MESH]

  • *{{pmid20038676}}
    *<b>[ Role of A-type lamins in signaling, transcription, and chromatin organization ]</b> J Cell Biol 2009; 187(7) ; 945-57 Andres V; Gonzalez JM


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    J Cell Biol

    945 7.187 2009