Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Cancer associated fibroblasts (CAFs) in tumor microenvironment Xing F; Saidou J; Watabe KFront Biosci (Landmark Ed) 2010[Jan]; 15 (1): 166-79Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.|*Cell Transformation, Neoplastic[MESH]|Animals[MESH]|Biomarkers, Tumor/metabolism[MESH]|Endothelial Cells/metabolism/pathology[MESH]|Epithelial Cells/metabolism/pathology[MESH]|Fibroblasts/*pathology[MESH]|Humans[MESH]|Mesoderm/metabolism/pathology[MESH]|Models, Biological[MESH]|Neoplasms/*pathology[MESH] |