Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Significance of des-gamma-carboxy prothrombin production in hepatocellular carcinoma Fujikawa T; Shiraha H; Yamamoto KActa Med Okayama 2009[Dec]; 63 (6): 299-304Serum des-gamma-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC. DCP-positive HCC demonstrates more aggressive clinicopathological features than DCP-negative HCC. Analysis of the biological effects of DCP revealed that DCP acts as a growth factor in both an autocrine and paracrine manner. DCP stimulates HCC cell proliferation through the Met-Janus kinase 1-signal transducer and activator of transcription 3 signaling pathway, whereas for vascular endothelial cells, it stimulates cell proliferation and migration through the kinase insert domain receptor-phospholipase C-gamma-mitogen-activated protein kinase signaling pathway.|Biomarkers, Tumor/*metabolism[MESH]|Biomarkers/*metabolism[MESH]|Carbon-Carbon Ligases/genetics/metabolism[MESH]|Carcinoma, Hepatocellular/diagnosis/*metabolism/pathology[MESH]|Cell Line, Tumor[MESH]|Cell Movement[MESH]|Cell Proliferation[MESH]|Endothelial Cells/physiology[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins/metabolism[MESH]|Liver Neoplasms/diagnosis/*metabolism/pathology[MESH]|Prognosis[MESH]|Protein Precursors/*metabolism[MESH]|Prothrombin/*metabolism[MESH]|Signal Transduction/physiology[MESH] |