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lüll Experimental evidence on the immunopathogenesis of primary biliary cirrhosis Selmi C; Meda F; Kasangian A; Invernizzi P; Tian Z; Lian Z; Podda M; Gershwin MECell Mol Immunol 2010[Jan]; 7 (1): 1-10Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data, including the presence of autoantibodies and autoreactive T cells. The etiology remains to be determined, yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset. Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host, mostly by molecular mimicry. Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria.|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|Disease Models, Animal[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Liver Cirrhosis, Biliary/chemically induced/genetics/*immunology/microbiology[MESH]|Xenobiotics/adverse effects[MESH] |