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lüll Central leptin receptor action and resistance in obesity Bjorbaek CJ Investig Med 2009[Oct]; 57 (7): 789-94The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.|Animals[MESH]|Brain/physiology[MESH]|Drug Resistance/genetics[MESH]|Leptin/physiology[MESH]|Obesity/genetics/*physiopathology[MESH]|Pro-Opiomelanocortin/physiology[MESH]|Receptors, Leptin/genetics/*physiology[MESH]|Signal Transduction[MESH] |