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lüll Epigenome manipulation as a pathway to new natural product scaffolds and their congeners Cichewicz RHNat Prod Rep 2010[Jan]; 27 (1): 11-22The covalent modification of chromatin is an important control mechanism used by fungi to modulate the transcription of genes involved in secondary metabolite production. To date, both molecular-based and chemical approaches targeting histone and DNA posttranslational processes have shown great potential for rationally directing the activation and/or suppression of natural-product-encoding gene clusters. In this Highlight, the organization of the fungal epigenome is summarized and strategies for manipulating chromatin-related targets are presented. Applications of these techniques are illustrated using several recently published accounts in which chemical-epigenetic methods and mutant studies were successfully employed for the de novo or enhanced production of structurally diverse fungal natural products (e.g., anthraquinones, cladochromes, lunalides, mycotoxins, and nygerones).|*Biological Products/biosynthesis/chemistry/genetics/isolation & purification[MESH]|Fungi/chemistry/*genetics/*metabolism[MESH]|Genome[MESH]|Molecular Structure[MESH]|Sequence Homology, Amino Acid[MESH]|Stereoisomerism[MESH] |