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lüll Wnt modulators in the biotech pipeline Rey JP; Ellies DLDev Dyn 2010[Jan]; 239 (1): 102-14The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.|*Models, Molecular[MESH]|Amino Acid Sequence[MESH]|Biotechnology/*trends[MESH]|Cystine Knot Motifs/genetics/*physiology[MESH]|LDL-Receptor Related Proteins/*chemistry/classification/metabolism[MESH]|Ligands[MESH]|Molecular Sequence Data[MESH]|Proteomics[MESH]|Signal Transduction/*physiology[MESH]|Wnt Proteins/*metabolism[MESH] |