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IL-17RC: a partner in IL-17 signaling and beyond Ho AW; Gaffen SLSemin Immunopathol 2010[Mar]; 32 (1): 33-42The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure-function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health.|Animals[MESH]|Autoimmunity/immunology[MESH]|Humans[MESH]|Inflammation/immunology[MESH]|Interleukin-17/*immunology[MESH]|Receptors, Interleukin-17/*immunology[MESH]|Signal Transduction/*immunology[MESH]|T-Lymphocyte Subsets/immunology[MESH]|T-Lymphocytes, Helper-Inducer/immunology[MESH] |
