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lüll Physiological and oncogenic Aurora-A pathway Saeki T; Ouchi M; Ouchi TInt J Biol Sci 2009[Nov]; 5 (7): 758-62Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.|*Cell Transformation, Neoplastic[MESH]|Animals[MESH]|Aurora Kinases[MESH]|BRCA1 Protein/metabolism[MESH]|Cell Cycle Proteins/metabolism[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/metabolism[MESH]|Neoplasms/*enzymology/genetics/metabolism[MESH]|Polo-Like Kinase 1[MESH]|Protein Serine-Threonine Kinases/*metabolism[MESH]|Proto-Oncogene Proteins/metabolism[MESH]|Signal Transduction[MESH]|TOR Serine-Threonine Kinases[MESH] |