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lüll Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors Chatal JF; Davodeau F; Cherel M; Barbet JJ Cancer Res Ther 2009[Sep]; 5 Suppl 1 (ä): S36-40Radioimmunotherapy (RIT) has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT) should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.|Animals[MESH]|Combined Modality Therapy[MESH]|Humans[MESH]|Neoplasms/*radiotherapy[MESH]|Radioimmunotherapy/methods[MESH] |