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lüll Autoimmune pancreatitis: report of two cases and literature review Sheng QS; Chen DZ; Lang R; He Q; Han DD; Pan F; Li P; Qu ZWHepatobiliary Pancreat Dis Int 2009[Dec]; 8 (6): 653-6BACKGROUND: Autoimmune pancreatitis (AIP) is a unique chronic inflammation of the pancreas in which autoimmune mechanisms are involved in the pathogenesis. It is characterized by clinical, histopathological, radiographic, serologic and therapeutic features. Since it was first described in 1995, increasing numbers of AIP patients have been diagnosed. METHODS: In this study, the data from 2 patients with AIP who had elevation of serum immunoglobulin G, positive autoantibody, swelling of the pancreas and narrowing of the main pancreatic duct on imaging were analyzed retrospectively. RESULTS: With the initial diagnosis of AIP, both patients underwent regular prednisone therapy, which was initiated at a dose of 40 mg per day with a tapering schedule of 5 mg every 2 weeks. The patients responded very well to treatment with prednisone. CONCLUSIONS: AIP is a relatively new disease entity. Although it is diagnosed by distinct characteristics of the clinical, radiologic, histopathologic, and serologic findings, many questions require further clarification, including its relationship to other autoimmune diseases and misdiagnosis as pancreaticobiliary malignancies.|*Pancreas/diagnostic imaging/immunology/pathology[MESH]|Adult[MESH]|Aged[MESH]|Anti-Inflammatory Agents/administration & dosage[MESH]|Antibodies, Antinuclear/blood[MESH]|Autoimmune Diseases/*diagnosis/drug therapy/immunology[MESH]|Biomarkers/blood[MESH]|Cholangiopancreatography, Magnetic Resonance[MESH]|Humans[MESH]|Immunoglobulin G/blood[MESH]|Male[MESH]|Pancreatitis/*diagnosis/drug therapy/immunology[MESH]|Prednisone/administration & dosage[MESH]|Tomography, X-Ray Computed[MESH]|Treatment Outcome[MESH] |