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Recognition of additional roles for immunoglobulin domains in immune function Cannon JP; Dishaw LJ; Haire RN; Litman RT; Ostrov DA; Litman GWSemin Immunol 2010[Feb]; 22 (1): 17-24Characterization of immune receptors found in phylogenetically disparate species at the genetic, structural and functional levels has provided unique insight into the evolutionary acquisition of immune function. The roles of variable- and intermediate-type immunoglobulin (Ig) domains in direct recognition of ligands and other functions are far wider than previously anticipated. Common mechanisms of multigene family diversification and expansion as well as unique adaptations that relate to function continue to provide unique insight into the numerous patterns, processes and complex interactions that regulate the host response to infectious challenge.|*Antibody Specificity[MESH]|Adaptive Immunity[MESH]|Animals[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|Immunoglobulins/chemistry/genetics/*immunology[MESH]|Multigene Family[MESH]|Receptors, Immunologic/immunology[MESH] |
