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Muc4/MUC4 functions and regulation in cancer Carraway KL; Theodoropoulos G; Kozloski GA; Carothers Carraway CAFuture Oncol 2009[Dec]; 5 (10): 1631-40The membrane mucin MUC4 (human) is abundantly expressed in many epithelia, where it is proposed to play a protective role, and is overexpressed in some epithelial tumors. Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms. In particular, Muc4/MUC4 can serve as a ligand/modulator of the receptor tyrosine kinase ErbB2, regulating its phosphorylation and the phosphorylation of its partner ErbB3, with or without the involvement of the ErbB3 ligand neuregulin. Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 expression is regulated by multiple mechanisms, ranging from transcriptional to post-translational. The roles of MUC4 in tumors suggest that it may be valuable as a tumor marker or target for therapy.|Animals[MESH]|Biomarkers, Tumor/*metabolism[MESH]|Humans[MESH]|Mucin-4/*metabolism[MESH]|Neoplasms/*metabolism[MESH]|Rats[MESH]|Signal Transduction/*physiology[MESH] |
