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lüll The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy Lin Y; Bai L; Chen W; Xu SExpert Opin Ther Targets 2010[Jan]; 14 (1): 45-55IMPORTANCE OF THE FIELD: Nuclear factor kappa B (NF-kappaB) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappaB and inflammatory cytokines makes NF-kappaB important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappaB activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappaB in cancer facilitates developing approaches for cancer prevention and therapy. AREAS COVERED IN THIS REVIEW: By searching PubMed, we summarize the progress of studies on NF-kappaB in carcinogenesis and cancer cells' drug resistance in recent 10 years. WHAT THE READER WILL GAIN: The mechanisms by which NF-kappaB activation pathways are activated; the roles and mechanisms of NF-kappaB in cell survival and proliferation, and in carcinogenesis and cancer cells' response to therapy; recent development of NF-kappaB-modulating means and their application in cancer prevention and therapy. TAKE HOME MESSAGE: NF-kappaB is involved in cancer development, modulating NF-kappaB activation pathways has important implications in cancer prevention and therapy. Due to the complexity of NF-kappaB roles in different cancers, careful evaluation of NF-kappaB's in each cancer type is crucial in this regard. More cancer cell-specific NF-kappaB inhibiting means are desired for improving anticancer efficacy and reducing systemic toxicity.|Animals[MESH]|Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]|Biotransformation/drug effects[MESH]|Cell Transformation, Neoplastic/drug effects[MESH]|DNA, Neoplasm/biosynthesis/genetics[MESH]|Genetic Therapy[MESH]|Humans[MESH]|I-kappa B Kinase/antagonists & inhibitors[MESH]|NF-kappa B/*drug effects/genetics/*physiology[MESH]|Neoplasm Metastasis/physiopathology/prevention & control[MESH]|Neoplasms/*drug therapy/*prevention & control[MESH]|Neovascularization, Pathologic/drug therapy/pathology[MESH]|Proteasome Endopeptidase Complex/drug effects[MESH]|Signal Transduction/*drug effects[MESH] |