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Critical appraisal of the role of pitavastatin in treating dyslipidemias and achieving lipid goals Saito YVasc Health Risk Manag 2009[]; 5 (ä): 921-36Pitavastatin is a potent HMG-CoA reductase inhibitor and efficient hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor inducer, producing robust reduction of the serum LDL-C levels, even at a low dose. Pitavastatin and its lactone form are minimally metabolized by CYP enzymes, and are therefore associated with minimal drug-drug interactions (DDIs). Pitavastatin 2 to 4 mg has potent LDL-C-reducing activity, equivalent to that of atorvastatin 10 to 20 mg; several clinical trials have revealed consistently superior high-density lipoprotein cholesterol (HDL-C) elevating activity of pitavastatin than that of atorvastatin. Pitavastatin-induced HDL-C elevation has been shown to be sustained, even incremental, in long-term clinical trials. Pitavastatin was as well-tolerated as atorvastatin or simvastatin in double-blind randomized clinical trials. Two-year long-term safety and effectiveness of pitavastain has been confirmed in a large-scale, prospective post-marketing surveillance. The safety and efficacy profile of pitavastatin is favorable for the treatment of dyslipidemia, especially in metabolic syndrome patients. In addition to control of LDL-C, adequate control of triglyceride (TG) and HDL-C, hypertension and hyperglycemia is also necessary in metabolic syndrome patients. Pitavastatin produces adequate control of LDL-C and TG, along with potent and incremental HDL-C elevation, with a low frequency of DDIs.|Animals[MESH]|Cholesterol, HDL/blood[MESH]|Cholesterol, LDL/blood[MESH]|Drug Interactions[MESH]|Dyslipidemias/blood/*drug therapy[MESH]|Humans[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/chemistry/pharmacokinetics/*therapeutic use[MESH]|Lipids/*blood[MESH]|Models, Molecular[MESH]|Molecular Structure[MESH]|Quinolines/adverse effects/chemistry/pharmacokinetics/*therapeutic use[MESH]|Structure-Activity Relationship[MESH]|Treatment Outcome[MESH]|Triglycerides/blood[MESH] |
