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lüll In vivo functions of GPR30/GPER-1, a membrane receptor for estrogen: from discovery to functions in vivo Mizukami YEndocr J 2010[]; 57 (2): 101-7G protein-coupled receptor 30/G protein-coupled estrogen receptor-1 (GPR30/GPER-1) was reported as a novel membrane receptor for estrogen in 2005. However, the research on GPR30 has produced conflicting reports with regard to its intracellular localization, the tissue distribution of its expression, and some its functions. Recently, in addition to the finding of G-1, a GPR30 agonist, GPR30 KO mice have been produced in laboratories, and this has significantly increased the confidence in the data. In this review, the intrinsic appearance of GPR30 is approached based mainly on data obtained in vivo.|Animals[MESH]|Glucose/metabolism[MESH]|Homeostasis[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|RNA, Messenger/metabolism[MESH]|Receptors, Estrogen/*physiology[MESH]|Receptors, G-Protein-Coupled/chemistry/genetics/*physiology[MESH]|Signal Transduction[MESH]|Tissue Distribution[MESH] |