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Frozen-thawed embryo transfer cycles Yeung WS; Li RH; Cheung TM; Ng EH; Lau EY; Ho PCHong Kong Med J 2009[Dec]; 15 (6): 420-6OBJECTIVE: To review the outcomes of frozen-thawed embryo transfer cycles. DESIGN. Retrospective review. SETTING: Tertiary assisted reproduction centre, Hong Kong. PATIENTS: Subfertile patients undergoing frozen-thawed embryo transfer between July 2005 and December 2007. MAIN OUTCOME MEASURES: Clinical and ongoing pregnancy rates. RESULTS: A total of 983 frozen-thawed embryo transfer cycles performed during the study period were reviewed. The clinical pregnancy and ongoing pregnancy rates were 35% and 30%, respectively. Factors associated with successful outcome included younger maternal age (<=35 years) and 4 or more blastomeres at replacement, but not the method of insemination, the cause of subfertility, or the type of frozen-thawed embryo transfer cycle. The overall multiple pregnancy rate was 18%. For cycles with a single embryo replaced, embryos having 4-cell or higher stages at replacement gave an ongoing pregnancy rate of 25%, whereas those with less than 4 cells had a significantly lower ongoing pregnancy rate of 5% only. Blastomere lysis after thawing significantly reduced the clinical pregnancy and ongoing pregnancy rates of cycles with one embryo replaced. CONCLUSIONS: Clinical pregnancy and ongoing pregnancy rates of frozen-thawed embryo transfer cycles were 35% and 30%, respectively. Higher pregnancy rates were associated with younger maternal age (<=35 years), blastomere numbers of 4 or more, and no blastomere lysis after thawing.|*Cryopreservation[MESH]|*Pregnancy Rate[MESH]|Adult[MESH]|Blastomeres/transplantation[MESH]|Embryo Transfer/*methods[MESH]|Female[MESH]|Humans[MESH]|Maternal Age[MESH]|Pregnancy[MESH]|Pregnancy, Multiple[MESH]|Retrospective Studies[MESH] |
