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Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells Maarof G; Bouchet-Delbos L; Gary-Gouy H; Durand-Gasselin I; Krzysiek R; Dalloul ABlood 2010[Mar]; 115 (9): 1718-26Complex molecular mechanisms control B-cell fate to become a memory or a plasma cell. Interleukin-24 (IL-24) is a class II family cytokine of poorly understood immune function that regulates the cell cycle. We previously observed that IL-24 is strongly expressed in leukemic memory-type B cells. Here we show that IL-24 is also expressed in human follicular B cells; it is more abundant in CD27(+) memory B cells and CD5-expressing B cells, whereas it is low to undetectable in centroblasts and plasma cells. Addition of IL-24 to B cells, cultured in conditions shown to promote plasma cell differentiation, strongly inhibited plasma cell generation and immunoglobulin G (IgG) production. By contrast, IL-24 siRNA increased terminal differentiation of B cells into plasma cells. IL-24 is optimally induced by BCR triggering and CD40 engagement; IL-24 increased CD40-induced B-cell proliferation and modulated the transcription of key factors involved in plasma cell differentiation. It also inhibited activation-induced tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT-3), and inhibited the transcription of IL-10. Taken together, our results indicate that IL-24 is a novel cytokine involved in T-dependent antigen (Ag)-driven B-cell differentiation and suggest its physiologic role in favoring germinal center B-cell maturation in memory B cells at the expense of plasma cells.|B-Lymphocytes/*cytology/*immunology[MESH]|Base Sequence[MESH]|CD40 Antigens/metabolism[MESH]|Cell Differentiation[MESH]|Cells, Cultured[MESH]|Gene Expression[MESH]|Germinal Center/*cytology/*immunology[MESH]|Humans[MESH]|Interleukins/antagonists & inhibitors/genetics/*immunology[MESH]|Plasma Cells/*cytology/*immunology[MESH]|RNA Interference[MESH]|RNA, Small Interfering/genetics[MESH] |
