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Cell signaling in space and time: where proteins come together and when they re apart Scott JD; Pawson TScience 2009[Nov]; 326 (5957): 1220-4Signal transduction can be defined as the coordinated relay of messages derived from extracellular cues to intracellular effectors. More simply put, information received on the cell surface is processed across the plasma membrane and transmitted to intracellular targets. This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to.|*Signal Transduction[MESH]|Animals[MESH]|Cell Compartmentation[MESH]|Cell Membrane/*metabolism[MESH]|Cell Nucleus/*metabolism[MESH]|Cytoplasm/*metabolism[MESH]|Enzymes/metabolism[MESH]|Humans[MESH]|MAP Kinase Signaling System[MESH]|Models, Biological[MESH]|Multiprotein Complexes/metabolism[MESH]|Protein Interaction Domains and Motifs[MESH]|Proteins/*metabolism[MESH]|Time Factors[MESH]|Transcription, Genetic[MESH] |
