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lüll Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding Bathe M; Chang FTrends Microbiol 2010[Jan]; 18 (1): 38-45Cytokinesis, the final stage of the cell division cycle, requires the proper placement, assembly and contraction of an actomyosin-based contractile ring. Conserved sets of cytokinesis proteins and pathways have now been identified and characterized functionally. Additionally, fluorescent protein fusion technology enables quantitative high-resolution imaging of protein dynamics in living cells. For these reasons, the study of cytokinesis is now ripe for quantitative, systems-level approaches. Here, we review our current understanding of the molecular mechanisms of contractile ring dynamics in the model organism Schizosaccharomyces pombe (fission yeast), focusing on recent examples that illustrate a synergistic integration of quantitative experimental data with computational modeling. A picture of a highly dynamic and integrated system consisting of overlapping networks is beginning to emerge, the detailed nature of which remains to be elucidated.|*Cytokinesis[MESH]|Actins/chemistry/metabolism/ultrastructure[MESH]|Contractile Proteins/chemistry/*metabolism/ultrastructure[MESH]|Fungal Proteins/chemistry/*metabolism/ultrastructure[MESH]|Microscopy, Fluorescence[MESH]|Schizosaccharomyces/*physiology[MESH]|Spectrometry, Fluorescence[MESH] |