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Do galectins play a role in venous thrombosis? a review Diaz JA; Ramacciotti E; Wakefield TWThromb Res 2010[May]; 125 (5): 373-6Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides on cell surfaces and extra cellular glycoproteins. They are involved in a variety of biological functions, including modulation of cell apoptosis, cell activation and inflammation. Our laboratory has recently identified galectin-3 binding protein (Gal-3BP) as being up-regulated in a microparticle proteomics analysis for deep venous thrombosis (DVT) patients compared to negative controls. P-selectin, another glycoprotein involved in thrombus propagation, has proven a promising target for DVT management and has been widely studied by our group. Galectins are involved in P-selectin expression and can potentially be implicated in the venous thrombogenesis process. The function of galectins, their role in inflammation and thrombosis as well as their potential implications as a new pharmacological target for DVT management are reviewed in this manuscript.|*Models, Cardiovascular[MESH]|Animals[MESH]|Galectins/*metabolism[MESH]|Humans[MESH]|Veins/*metabolism[MESH]|Venous Thrombosis/*metabolism[MESH] |
