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Thrombopoietin in normal and neoplastic stem cell development Kaushansky K; Ranney HMBest Pract Res Clin Haematol 2009[Dec]; 22 (4): 495-9It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V(617)F.|Animals[MESH]|Hematopoietic Stem Cells/*metabolism[MESH]|Humans[MESH]|Myeloproliferative Disorders/*metabolism[MESH]|Proto-Oncogene Mas[MESH]|Receptors, Thrombopoietin/metabolism[MESH]|Thrombopoietin/*metabolism[MESH] |
